A new Antibody Neutralizes All Known Covid Variants

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A group of researchers from the Boston Children Hospital have reportedly created powerful new antibody that neutralizes all known Covid variants. “It neutralized all known SARS-CoV-2 variants of concern, including all Omicron variants,” reports Science Tech Daily.

We hope that this humanized antibody will prove to be as effective at neutralizing SARS-CoV-2 in patients as it has proven to be thus far in preclinical evaluations.

– Frederick Alt, Ph.D., of the Program in Cellular and Molecular Medicine at Boston Children’s Hospital (source: Science Tech Daily)

The study published recently in Science Immunology reportedly utilized a “modified version of a humanized mouse model that his lab had previously used to look for broadly neutralizing antibodies to HIV”.

Science Tech Daily writes “The researchers initially introduced two human gene segments into the mice, causing their B cells to create a wide repertoire of humanized antibodies in a short period of time. They subsequently exposed the mice to the original Wuhan-Hu-1 strain of the virus’s SARS-CoV-2 spike protein, which is the main protein targeted by our antibodies and current vaccines. The modified mice developed nine lineages, or ‘families’, of humanized antibodies that bonded to the spike in response.”

Alex Kreutzberger, Ph.D. and Tomas Kirchhausen, Ph.D., of Boston Children’s Hospital, showed in their studies that “using a novel live-cell imaging platform, the SP1-77 prevents the virus from fusing its outer membrane with the membrane of the target cell. This thwarts the final necessary step that throws the door open to infection”.