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COVID Vaccines

CDC: Moderna Vaccine is the Most Effective

In a recent head to head study by the US Centers of Disease Control and Prevention (CDC), all three authorized Coronavirus vaccines were compared for their comparative effusiveness against hospitalization and found that effectiveness against Covid was higher for the Moderna vaccine (93%) than the Pfizer-BioNTech vaccine (88%) and the Janssen vaccine (71%).

Although these real-world data suggest some variation in levels of protection by vaccine, all FDA-approved or authorized COVID-19 vaccines provide substantial protection against COVID-19 hospitalization.

CDC’s weekly report on death and disease, the MMWR.

According to the CDC researchers “the biggest difference between the vaccine made by Moderna and Pfizer/BioNtech’s vaccine was driven by a decline that started about four months after people were fully vaccinated with Pfizer’s vaccine”.

“Differences in vaccine effectiveness between the Moderna and Pfizer-BioNTech vaccine might be due to higher mRNA content in the Moderna vaccine, differences in timing between doses (3 weeks for Pfizer-BioNTech versus 4 weeks for Moderna), or possible differences between groups that received each vaccine that were not accounted for in the analysis,” the team wrote.

“Vaccine effectiveness for the Pfizer-BioNTech vaccine was 91% at 14 -120 days after receipt of the second vaccine dose but declined significantly to 77% at more than 120 days,” added the team.

The CDC researchers wrote”A single dose of the Janssen viral vector vaccine had comparatively lower anti-SARS-CoV-2 antibody response and vaccine effectiveness against COVID-19 hospitalizations. Understanding differences in vaccine effectiveness by vaccine product can guide individual choices and policy recommendations regarding vaccine boosters. All FDA-approved or authorized COVID-19 vaccines provide substantial protection against COVID-19 hospitalization.”

“These real-world data suggest that the two-dose Moderna and Pfizer-BioNTech mRNA vaccine regimens provide more protection than does the one-dose Janssen viral vector vaccine regimen. Although the Janssen vaccine had lower observed vaccine effectiveness, one dose of Janssen vaccine still reduced risk for COVID-19-associated hospitalization by 71%,” the CDC researchers wrote.

According to CDC’s team of researchers the study’s limitation were “this analysis did not consider children, immunocompromised adults, or vaccine effectiveness against COVID-19 that did not result in hospitalization”.

The study was reportedly conducted across the US with 3,689 patients at 21 hospitals in 18 states, where researchers looked at antibodies in the blood of 100 healthy volunteers after they had been vaccinated with one of the three available vaccines. The volunteers were only followed for 29 weeks — just over six months.

Coronavirus-19 vaccination watch

According to the US Centers for Disease Control and Prevention (CDC) COVID vaccination tracker page (as of September 20, 9 a.m.) 466,535,855 doses have been distributed and 386,237,881 doses administered. According MDH COVID-19 Response vaccine data (as of September 16) a total of 6,340,399 doses of Covid-19 (Pfizer & Moderna) vaccines have been administered in Minnesota. According to the MDH latest tally (as of September 20) the confirmed COVID-19 cases in Minnesota are 684,070 (out of 12,051,773 tested) with 7,993 deaths.